Andre Villas-Boas’ men are bidding to do the double on the Red Devils having beaten them 3-2 in a thriller at Old Trafford back in December.
However that win ended a run of 22 games against Sir Alex’s men without a win and the visitors have won 8 and lost none of their last 11 games at White Hart Lane.
Spurs will clearly have to be right at the top of their game to win this but they do come into the game in very good form and have lost just one of their last 10 games in the league.
The one worrying factor this season is that they have lost their last four games against other teams in the top six of the table, but if they can keep Robin van Persie and Wayne Rooney at bay they have the ability to put that record straight.
Much will depend on how their defence holds up, and they will be reliant on the likes of Jermaine Defoe and Gareth Bale to capitalise on chances created at the other end of the pitch.
Over 2.5 goals looks a pretty solid punt at 1.62 with Betfred given the attacking capabilities of both sides in what promises to be an end-to-end encounter, and in the correct score market I would plump for a 2-1 Spurs victory.