We know that Gareth Bale and Aaron Lennon will sit this one out and the pair will join Younes Kaboul, Jermain Defoe and Sandro on the sidelines. The starting XI may well pick itself as a result but what will the formation be at White Hart Lane on Sunday?
Hugo Lloris should return in goal with Kyle Walker set to resume at right back following European suspension. After BAE’s display at left back on Thursday, Kyle Naughton could well be switched over to that side of the field.
Up front, the only real question is whether Adebayor plays as a lone front man or if Clint Dempsey joins him in a 4-4-2. Behind the striker(s), Parker, Dembele, Sigurdsson and Holtby seem set to start but where will they slot in?
Here’s how we think Spurs will look from the first whistle but what’s your view?