Jose Mourinho has made two changes from the Tottenham side that beat Manchester City in their previous Premier League match.
Inform midfielder Giovani Lo Celso is only fit enough for a place on the bench, meaning Eric Dier is handed his first league start since the defeat to Chelsea on 22 December and partners Harry Winks in a two-man midfield.
Elsewhere, Ben Davies has finally returned from a two-month lay-off with an ankle injury and starts at left-back – with Japhet Tanganga joining Tanguy Ndombele among the substitutes.
The hero against City, Steven Bergwijn, is back in the starting XI after he was ineligible to feature in the FA Cup victory over Southampton last week and joins Heung Min Son – who has scored in each of his previous four Spurs appearances – Dele Alli and Lucas Moura in a familiar front-four for Tottenham.
There is no place in the matchday squad for summer signing Ryan Sessegnon.
Starting XI: Lloris, Aurier, Sanchez, Alderweireld, Davies, Winks, Dier, Son Alli, Bergwijn, Lucas.
Substitutes: Gazzaniga, Vertonghen, Tanganga, Ndombele, Skipp, Gedson, Lo Celso.