Janssen spent the 2017-18 campaign on loan at Turkish club Fenerbahce, where he scored five goals in 17 appearances across all competitions.
Previous reports had suggested Fenerbahce would be interested in taking Janssen on loan for another season, but those rumours have gone quiet in recent weeks.
Janssen joined Spurs from FC Twente for £17 million in the summer of 2016 but endured a difficult debut season in England, scoring just six goals, four of which were penalties.
The 23-year-old is expected to leave Tottenham this summer, as is Fernando Llorente.
Sevilla are also said to be keen on Ajax forward Kasper Dolberg, who has been linked with Spurs in the past.
I don’t think Tottenham will be too concerned about where Janssen ends up so long as they receive a decent fee for him.
If Sevilla don’t make a sufficient offer to sign Janssen permanently, I can see him heading off to Fernerbahce on loan again.